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MRI signal distribution within the intervertebral disc as a biomarker of adolescent idiopathic scoliosis and spondylolisthesis

Julien Gervais, Delphine Périé-Curnier, Stefan Parent, Hubert Labelle, Carl-Éric Aubin

Article (2012)

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Abstract

Background: Early stages of scoliosis and spondylolisthesis entail changes in the intervertebral disc (IVD) structure and biochemistry. The current clinical use of MR T2-weighted images is limited to visual inspection. Our hypothesis is that the distribution of the MRI signal intensity within the IVD in T2-weighted images depends on the spinal pathology and on its severity. Therefore, this study aims to develop the AMRSID (analysis of MR signal intensity distribution) method to analyze the 3D distribution of the MR signal intensity within the IVD and to evaluate their sensitivity to scoliosis and spondylolisthesis and their severities. Methods: This study was realized on 79 adolescents who underwent a MRI acquisition (sagittal T2-weighted images) before their orthopedic or surgical treatment. Five groups were considered: low severity scoliosis (Cobb angle <= 50 degrees), high severity scoliosis (Cobb angles >50 degrees), low severity spondylolisthesis (Meyerding grades I and II), high severity spondylolisthesis (Meyerding grades III, IV and V) and control. The distribution of the MRI signal intensity within the IVD was analyzed using the descriptive statistics of histograms normalized by either cerebrospinal fluid or bone signal intensity, weighted centers and volume ratios. Differences between pathology and severity groups were assessed using one-and two-way ANOVAs. Results: There were significant (p < 0.05) variations of indices between scoliosis, spondylolithesis and control groups and between low and high severity groups. The cerebrospinal fluid normalization was able to detect differences between healthy and pathologic IVDs whereas the bone normalization, which reflects both bone and IVD health, detected more differences between the severities of these pathologies. Conclusions: This study proves for the first time that changes in the intervertebral disc, non visible to the naked eye on sagittal T2-weighted MR images of the spine, can be detected from specific indices describing the distribution of the MR signal intensity. Moreover, these indices are able to discriminate between scoliosis and spondylolisthesis and their severities, and provide essential information on the composition and structure of the discs whatever the pathology considered. The AMRSID method may have the potential to complement the current diagnostic tools available in clinics to improve the diagnostic with earlier biomarkers, the prognosis of evolution and the treatment options of scoliosis and spondylolisthesis.

Uncontrolled Keywords

Adolescent; Analysis of Variance; Case-Control Studies; Child; Humans; Image Interpretation, Computer-Assisted; Imaging, Three-Dimensional; Intervertebral Disc; Intervertebral Disc Degeneration; Magnetic Resonance Imaging; Predictive Value of Tests; Prognosis; Scoliosis; Sensitivity and Specificity; Severity of Illness Index; Spondylolisthesis; Young Adult

Subjects: 1900 Biomedical engineering > 1903 Biomechanics
2100 Mechanical engineering > 2100 Mechanical engineering
9000 Health sciences > 9000 Health sciences
Department: Department of Mechanical Engineering
Funders: CRSNG / NSERC, Foundation of Stars, Foundation of CHU Sainte-Justine, Groupe de recherche en science et en technologie biomédicales (GRSTB), Fonds de recherche en santé du Québec (FRSQ), Foundation of École Polytechnique, Scoliosis Research Society
PolyPublie URL: https://publications.polymtl.ca/3415/
Journal Title: BMC Musculoskeletal Disorders (vol. 13)
Publisher: BioMed Central Ltd
DOI: 10.1186/1471-2474-13-239
Official URL: https://doi.org/10.1186/1471-2474-13-239
Date Deposited: 22 Nov 2018 11:50
Last Modified: 11 Nov 2022 13:50
Cite in APA 7: Gervais, J., Périé-Curnier, D., Parent, S., Labelle, H., & Aubin, C.-É. (2012). MRI signal distribution within the intervertebral disc as a biomarker of adolescent idiopathic scoliosis and spondylolisthesis. BMC Musculoskeletal Disorders, 13. https://doi.org/10.1186/1471-2474-13-239

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