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Terahertz dielectric spectroscopy and solid immersion microscopy of ex vivo glioma model 1018: brain tissue heterogeneity

A. S. Kucheryavenko, N. V. Chernomyrdin, A. A. Gavdush, A. I. Alekseeva, P. V. Nikitin, I. N. Dolganova, P. A. Karalkin, A. S. Khalansky, I. E. Spektor, Maksim A. Skorobogatiy, V. V. Tuchin and K. I. Zaytsev

Article (2021)

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Terahertz (THz) technology holds strong potential for the intraoperative label-free diagnosis of brain gliomas, aimed at ensuring their gross-total resection. Nevertheless, it is still far from clinical applications due to the limited knowledge about the THz-wave–brain tissue interactions. In this work, rat glioma model 101.8 was studied ex vivo using both the THz pulsed spectroscopy and the 0.15λ-resolution THz solid immersion microscopy (λ is a free-space wavelength). The considered homograft model mimics glioblastoma, possesses heterogeneous character, unclear margins, and microvascularity. Using the THz spectroscopy, effective THz optical properties of brain tissues were studied, as averaged within the diffraction-limited beam spot. Thus measured THz optical properties revealed a persistent difference between intact tissues and a tumor, along with fluctuations of the tissue response over the rat brain. The observed THz microscopic images showed heterogeneous character of brain tissues at the scale posed by the THz wavelengths, which is due to the distinct response of white and gray matters, the presence of different neurovascular structures, as well as due to the necrotic debris and hemorrhage in a tumor. Such heterogeneities might significantly complicate delineation of tumor margins during the intraoperative THz neurodiagnosis. The presented results for the first time pose the problem of studying the inhomogeneity of brain tissues that causes scattering of THz waves, as well as the urgent need to use the radiation transfer theory for describing the THz-wave — tissue interactions.

Subjects: 1900 Biomedical engineering > 1900 Biomedical engineering
1900 Biomedical engineering > 1901 Biomedical technology
3100 Physics > 3100 Physics
3100 Physics > 3110 Optics (see also Photon devices, 2505)
Department: Department of Engineering Physics
Funders: Russian Foundation for Basic Research, Russian Science Foundation
Grant number: 18-29-02060, 17-79-20346
PolyPublie URL: https://publications.polymtl.ca/9355/
Journal Title: Biomedical Optics Express (vol. 12, no. 8)
Publisher: Optica Publishing Group
DOI: 10.1364/boe.432758
Official URL: https://doi.org/10.1364/boe.432758
Date Deposited: 07 Sep 2023 10:02
Last Modified: 09 Apr 2024 20:02
Cite in APA 7: Kucheryavenko, A. S., Chernomyrdin, N. V., Gavdush, A. A., Alekseeva, A. I., Nikitin, P. V., Dolganova, I. N., Karalkin, P. A., Khalansky, A. S., Spektor, I. E., Skorobogatiy, M. A., Tuchin, V. V., & Zaytsev, K. I. (2021). Terahertz dielectric spectroscopy and solid immersion microscopy of ex vivo glioma model 1018: brain tissue heterogeneity. Biomedical Optics Express, 12(8), 5272-5289. https://doi.org/10.1364/boe.432758


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