<  Back to the Polytechnique Montréal portal

Comparison of antimicrobial properties of inorganic peroxide polymer composites

Dario Job, Joane Matta, Cat‐Thy Dang, Yara Raphael, Joshua Vorstenbosch, Bentolhoda Helli, Géraldine Merle and Jake E. Barralet

Article (2024)

Open Acess document in PolyPublie and at official publisher
Open Access to the full text of this document
Published Version
Terms of Use: Creative Commons Attribution
Download (4MB)
Show abstract
Hide abstract


Wound healing and prevention of bacterial infections are critical aspects of modern medical care. In this work, antibacterial films were produced by creating composites of polycaprolactone with inorganic peroxides. Calcium, magnesium, and zinc peroxide were incorporated in a biocompatible polymeric film. Iron oxide, sodium bicarbonate, and calcium phosphate were added to reduce hydrogen peroxide and to maintain pH in a less alkaline range, allowing for optimization of the material's antibacterial efficacy while minimizing cytotoxicity toward human fibroblasts. Experiments with common wound pathogens, Staphylococcus aureus and Pseudomonas aerugonisa, confirmed significant and prolonged antibacterial effects of peroxide-doped films. Findings showed that the addition of CaO2 and MgO2 within the film increased cytotoxicity toward human fibroblasts after 48 h (30%–40% decrease compared to control), whereas ZnO2-based films exhibited a minimal cytotoxicity consistently maintaining over 70% cell viability throughout the course of the experiment. We examined the materials’ sustained release of reactive oxygen species and oxygen, and pH variation correlated with antibacterial activity. Given the unique combination of antibacterial efficacy and mammalian biocompatibility, these peroxides have value as components to sustain hydrogen peroxide release when appropriately compounded to reduce pH variation and avoid excessive hydrogen peroxide levels.

Uncontrolled Keywords

bacteria; hydrogen peroxide; inorganic; oxygen; peroxide; wound

Subjects: 1800 Chemical engineering > 1800 Chemical engineering
1800 Chemical engineering > 1802 Biochemical engineering
Department: Department of Chemical Engineering
Funders: NSERC / CRSNG Discovery Grants, Fonds de recherche du Québec - Santé
PolyPublie URL: https://publications.polymtl.ca/57908/
Journal Title: MedComm – Biomaterials and Applications (vol. 3, no. 1)
Publisher: John Wiley & Sons
DOI: 10.1002/mba2.75
Official URL: https://doi.org/10.1002/mba2.75
Date Deposited: 14 May 2024 09:51
Last Modified: 15 May 2024 22:24
Cite in APA 7: Job, D., Matta, J., Dang, C.‐T., Raphael, Y., Vorstenbosch, J., Helli, B., Merle, G., & Barralet, J. E. (2024). Comparison of antimicrobial properties of inorganic peroxide polymer composites. MedComm – Biomaterials and Applications, 3(1), e75 (13 pages). https://doi.org/10.1002/mba2.75


Total downloads

Downloads per month in the last year

Origin of downloads


Repository Staff Only

View Item View Item