Dario Job, Joane Matta, Cat‐Thy Dang, Yara Raphael, Joshua Vorstenbosch, Bentolhoda Helli, Géraldine Merle et Jake E. Barralet
Article de revue (2024)
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Libre accès au plein texte de ce document Version officielle de l'éditeur Conditions d'utilisation: Creative Commons: Attribution (CC BY) Télécharger (4MB) |
Abstract
Wound healing and prevention of bacterial infections are critical aspects of modern medical care. In this work, antibacterial films were produced by creating composites of polycaprolactone with inorganic peroxides. Calcium, magnesium, and zinc peroxide were incorporated in a biocompatible polymeric film. Iron oxide, sodium bicarbonate, and calcium phosphate were added to reduce hydrogen peroxide and to maintain pH in a less alkaline range, allowing for optimization of the material's antibacterial efficacy while minimizing cytotoxicity toward human fibroblasts. Experiments with common wound pathogens, Staphylococcus aureus and Pseudomonas aerugonisa, confirmed significant and prolonged antibacterial effects of peroxide-doped films. Findings showed that the addition of CaO2 and MgO2 within the film increased cytotoxicity toward human fibroblasts after 48 h (30%–40% decrease compared to control), whereas ZnO2-based films exhibited a minimal cytotoxicity consistently maintaining over 70% cell viability throughout the course of the experiment. We examined the materials’ sustained release of reactive oxygen species and oxygen, and pH variation correlated with antibacterial activity. Given the unique combination of antibacterial efficacy and mammalian biocompatibility, these peroxides have value as components to sustain hydrogen peroxide release when appropriately compounded to reduce pH variation and avoid excessive hydrogen peroxide levels.
Mots clés
bacteria; hydrogen peroxide; inorganic; oxygen; peroxide; wound
Sujet(s): |
1800 Génie chimique > 1800 Génie chimique 1800 Génie chimique > 1802 Génie biochimique |
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Département: | Département de génie chimique |
Organismes subventionnaires: | NSERC / CRSNG Discovery Grants, Fonds de recherche du Québec - Santé |
URL de PolyPublie: | https://publications.polymtl.ca/57908/ |
Titre de la revue: | MedComm – Biomaterials and Applications (vol. 3, no 1) |
Maison d'édition: | John Wiley & Sons |
DOI: | 10.1002/mba2.75 |
URL officielle: | https://doi.org/10.1002/mba2.75 |
Date du dépôt: | 14 mai 2024 09:51 |
Dernière modification: | 15 mai 2024 22:24 |
Citer en APA 7: | Job, D., Matta, J., Dang, C.‐T., Raphael, Y., Vorstenbosch, J., Helli, B., Merle, G., & Barralet, J. E. (2024). Comparison of antimicrobial properties of inorganic peroxide polymer composites. MedComm – Biomaterials and Applications, 3(1), e75 (13 pages). https://doi.org/10.1002/mba2.75 |
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