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Sustainable manufacture of insect repellents derived from Nepeta cataria

Gregory Patience, Ginette Karirekinyana, Federico Galli, Nicolas A. Patience, Cariton Kubwabo, Guy Collin, Jean Claude Bizimana, Daria Camilla Boffito

Article (2018)

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Malaria devastates sub-Saharan Africa; the World Health Organization (WHO) estimates that 212 million people contract malaria annually and that the plasmodium virus will kill 419 000 in 2017. The disease affects rural populations who have the least economic means to fight it. Impregnated mosquito nets have reduced the mortality rate but the Anopheles mosquitoes are changing their feeding patterns and have become more active at dusk and early morning rather than after 22h00 as an adaptation to the nets. Everyone is susceptible to the Anopheles at these times but infants and pregnant women are the most vulnerable to the disease. Plant-based mosquito repellents are as effective as synthetic repellents that protect people from bites. They are sustainable preventative measures against malaria not only because of their efficacy but because the local population can produce and distribute them, which represents a source of economic growth for rural areas. Here, we extract and test the essential oil nepetalactone from Nepeta cataria via steam distillation. Families in endemic areas of Burundi found them effective against bites but commented that the odor was pungent. An epidemiological study is required to establish its clinical efficacy.

Uncontrolled Keywords

Animals; Anopheles/*drug effects/parasitology; Burundi; Insect Repellents/*chemistry/*pharmacology; Insect Vectors/drug effects/parasitology; Malaria/*prevention & control/transmission; Nepeta/*chemistry; Oils, Volatile/chemistry/pharmacology; Plant Oils/chemistry/*pharmacology

Subjects: 1800 Chemical engineering > 1800 Chemical engineering
Department: Department of Chemical Engineering
Funders: French Ambassador, Batwa of Matara, ABEM, Aliksir, ALUMA, ACVE
PolyPublie URL: https://publications.polymtl.ca/5078/
Journal Title: Scientific Reports (vol. 8, no. 1)
Publisher: Nature
DOI: 10.1038/s41598-017-18141-z
Official URL: https://doi.org/10.1038/s41598-017-18141-z
Date Deposited: 03 Jun 2022 14:50
Last Modified: 23 May 2023 12:47
Cite in APA 7: Patience, G., Karirekinyana, G., Galli, F., Patience, N. A., Kubwabo, C., Collin, G., Bizimana, J. C., & Boffito, D. C. (2018). Sustainable manufacture of insect repellents derived from Nepeta cataria. Scientific Reports, 8(1), 2235 (9 pages). https://doi.org/10.1038/s41598-017-18141-z


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