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Statistical atlas-based descriptor for an early detection of optic disc abnormalities

Fantin Girard, Conrad Kavalec, Farida Cheriet

Article (2018)

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Abstract

Optic disc (OD) appearance in fundus images is one of the clinical indicators considered in the assessment of retinal diseases such as glaucoma. The cup-to-disc ratio (CDR) is the most common clinical measurement used to characterize glaucoma. However, the CDR only evaluates the relative sizes of the cup and the OD via their diameters. We propose to construct an atlas-based shape descriptor (ASD) to statistically characterize the geometric deformations of the OD shape and of the blood vessels' configuration inside the OD region. A local representation of the OD region is proposed to construct a well-defined statistical atlas using nonlinear registration and statistical analysis of deformation fields. The shape descriptor is defined as being composed of several statistical measures from the atlas. Analysis of the average model and its principal modes of deformation are performed on a healthy population. The components of the ASD show a significant difference between pathological and healthy ODs. We show that the ASD is able to characterize healthy and glaucomatous OD regions. The deviation map extracted from the atlas can be used to assist clinicians in an early detection of deformation abnormalities in the OD region.

Uncontrolled Keywords

atlases; fundus imaging; registration; retina

Subjects: 1900 Biomedical engineering > 1901 Biomedical technology
2800 Artificial intelligence > 2800 Artificial intelligence (Computer vision, see 2603)
Department: Department of Computer Engineering and Software Engineering
Funders: MÉDITIS, CRSNG/NSERC
Grant number: RDCPJ 484993-15
PolyPublie URL: https://publications.polymtl.ca/4894/
Journal Title: Journal of Medical Imaging (vol. 5, no. 1)
Publisher: SPIE
DOI: 10.1117/1.jmi.5.1.014006
Official URL: https://doi.org/10.1117/1.jmi.5.1.014006
Date Deposited: 13 Jan 2022 14:05
Last Modified: 11 Nov 2022 14:28
Cite in APA 7: Girard, F., Kavalec, C., & Cheriet, F. (2018). Statistical atlas-based descriptor for an early detection of optic disc abnormalities. Journal of Medical Imaging, 5(1), 014006 (14 pages). https://doi.org/10.1117/1.jmi.5.1.014006

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