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Dendrimers as anti-inflammatory agents

Pramod Kumar Avti et Ashok Kakkar

Communication écrite (2011)

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Abstract

Abstract: Dendrimers constitute an intriguing class of macromolecules which find applications in a variety of areas including biology. These hyperbranched macromolecules with tailored backbone and surface groups have been extensively investigated as nanocarriers for gene and drug delivery, by molecular encapsulation or covalent conjugation. Dendrimers have provided an excellent platform to develop multivalent and multifunctional nanoconjugates incorporating a variety of functional groups including drugs which are known to be anti-inflammatory agents. Recently, dendrimers have been shown to possess anti-inflammatory properties themselves. This unexpected and intriguing discovery has provided an additional impetus in designing novel active pharmaceutical agents. In this review, we highlight some of the recent developments in the field of dendrimers as nanoscale anti-inflammatory agents.

Mots clés

Dendrimers, Nanocarriers, Anti-inflammatory agents, Cyclooxygenase (COX-2), Inducible nitric oxide synthase (iNOS), Pro-inflammatory cytokines, Dendrímeros, Nanotransportadores, Agentes antiinflamatórios, Ciclooxigenase (COX-2), Óxido nítrico sintase induzível (iNOS), Citocinas pró-inflamatórias

Sujet(s): 1900 Génie biomédical > 1900 Génie biomédical
5300 Biologie moléculaire > 5300 Biologie moléculaire
Département: Institut de génie biomédical
Organismes subventionnaires: CRSNG/NSERC, Fonds de Recherche Nature et Technologie Québec (FQRNT)
URL de PolyPublie: https://publications.polymtl.ca/4761/
Nom de la conférence: Dendrimer Symposium: Significance in the Context of Nanotechnology
Lieu de la conférence: Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil
Date(s) de la conférence: 2011-10-01
Titre de la revue: Brazilian Journal of Pharmaceutical Sciences (vol. 49, no spe)
Maison d'édition: Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
DOI: 10.1590/s1984-82502013000700006
URL officielle: https://doi.org/10.1590/s1984-82502013000700006
Date du dépôt: 12 mars 2021 15:52
Dernière modification: 31 oct. 2023 12:31
Citer en APA 7: Avti, P. K., & Kakkar, A. (octobre 2011). Dendrimers as anti-inflammatory agents [Communication écrite]. Dendrimer Symposium: Significance in the Context of Nanotechnology, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil. Publié dans Brazilian Journal of Pharmaceutical Sciences, 49(spe). https://doi.org/10.1590/s1984-82502013000700006

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