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Dendrimers as anti-inflammatory agents

Pramod Kumar Avti and Ashok Kakkar

Paper (2011)

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Abstract

Abstract: Dendrimers constitute an intriguing class of macromolecules which find applications in a variety of areas including biology. These hyperbranched macromolecules with tailored backbone and surface groups have been extensively investigated as nanocarriers for gene and drug delivery, by molecular encapsulation or covalent conjugation. Dendrimers have provided an excellent platform to develop multivalent and multifunctional nanoconjugates incorporating a variety of functional groups including drugs which are known to be anti-inflammatory agents. Recently, dendrimers have been shown to possess anti-inflammatory properties themselves. This unexpected and intriguing discovery has provided an additional impetus in designing novel active pharmaceutical agents. In this review, we highlight some of the recent developments in the field of dendrimers as nanoscale anti-inflammatory agents.

Uncontrolled Keywords

Dendrimers, Nanocarriers, Anti-inflammatory agents, Cyclooxygenase (COX-2), Inducible nitric oxide synthase (iNOS), Pro-inflammatory cytokines, Dendrímeros, Nanotransportadores, Agentes antiinflamatórios, Ciclooxigenase (COX-2), Óxido nítrico sintase induzível (iNOS), Citocinas pró-inflamatórias

Subjects: 1900 Biomedical engineering > 1900 Biomedical engineering
5300 Molecular biology > 5300 Molecular biology
Department: Institut de génie biomédical
Funders: CRSNG/NSERC, Fonds de Recherche Nature et Technologie Québec (FQRNT)
PolyPublie URL: https://publications.polymtl.ca/4761/
Conference Title: Dendrimer Symposium: Significance in the Context of Nanotechnology
Conference Location: Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil
Conference Date(s): 2011-10-01
Journal Title: Brazilian Journal of Pharmaceutical Sciences (vol. 49, no. spe)
Publisher: Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
DOI: 10.1590/s1984-82502013000700006
Official URL: https://doi.org/10.1590/s1984-82502013000700006
Date Deposited: 12 Mar 2021 15:52
Last Modified: 10 Apr 2024 09:08
Cite in APA 7: Avti, P. K., & Kakkar, A. (2011, October). Dendrimers as anti-inflammatory agents [Paper]. Dendrimer Symposium: Significance in the Context of Nanotechnology, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil. Published in Brazilian Journal of Pharmaceutical Sciences, 49(spe). https://doi.org/10.1590/s1984-82502013000700006

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