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Dendrimers as anti-inflammatory agents

Pramod K. Avti and Ashok Kakkar

Conference or Workshop Item - Paper (2013)

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Cite this document: Avti, P. K. & Kakkar, A. (2011, October). Dendrimers as anti-inflammatory agents. Paper presented at Dendrimer Symposium: Significance in the Context of Nanotechnology, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil. doi:10.1590/s1984-82502013000700006
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Abstract

Abstract: Dendrimers constitute an intriguing class of macromolecules which find applications in a variety of areas including biology. These hyperbranched macromolecules with tailored backbone and surface groups have been extensively investigated as nanocarriers for gene and drug delivery, by molecular encapsulation or covalent conjugation. Dendrimers have provided an excellent platform to develop multivalent and multifunctional nanoconjugates incorporating a variety of functional groups including drugs which are known to be anti-inflammatory agents. Recently, dendrimers have been shown to possess anti-inflammatory properties themselves. This unexpected and intriguing discovery has provided an additional impetus in designing novel active pharmaceutical agents. In this review, we highlight some of the recent developments in the field of dendrimers as nanoscale anti-inflammatory agents.

Uncontrolled Keywords

Dendrimers, Nanocarriers, Anti-inflammatory agents, Cyclooxygenase (COX-2), Inducible nitric oxide synthase (iNOS), Pro-inflammatory cytokines, Dendrímeros, Nanotransportadores, Agentes antiinflamatórios, Ciclooxigenase (COX-2), Óxido nítrico sintase induzível (iNOS), Citocinas pró-inflamatórias

Open Access document in PolyPublie
Subjects: 1900 Génie biomédical > 1900 Génie biomédical
5300 Biologie moléculaire > 5300 Biologie moléculaire
Department: Institut de génie biomédical
Polytechnique Montréal > Centres de recherche > Institut de génie biomédical
Research Center: Non applicable
Funders: CRSNG/NSERC, Fonds de Recherche Nature et Technologie Québec (FQRNT)
Date Deposited: 12 Mar 2021 15:52
Last Modified: 08 Apr 2021 10:43
PolyPublie URL: https://publications.polymtl.ca/4761/
Document issued by the official publisher
Conference Title: Dendrimer Symposium: Significance in the Context of Nanotechnology
Conference Location: Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil
Conference Date(s): 2011-10-01
Journal Title: Brazilian Journal of Pharmaceutical Sciences (vol. 49)
Publisher: Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Official URL: https://doi.org/10.1590/s1984-82502013000700006

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