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Alkyne-Azide “click” chemistry in designing nanocarriers for applications in biology

Pramod K. Avti, Dusica Maysinger, Ashok Kakkar

Article (2013)

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Abstract

The alkyne-azide cycloaddition, popularly known as the "click" reaction, has been extensively exploited in molecule/macromolecule build-up, and has offered tremendous potential in the design of nanomaterials for applications in a diverse range of disciplines, including biology. Some advantageous characteristics of this coupling include high efficiency, and adaptability to the environment in which the desired covalent linking of the alkyne and azide terminated moieties needs to be carried out. The efficient delivery of active pharmaceutical agents to specific organelles, employing nanocarriers developed through the use of "click" chemistry, constitutes a continuing topical area of research. In this review, we highlight important contributions click chemistry has made in the design of macromolecule-based nanomaterials for therapeutic intervention in mitochondria and lipid droplets.

Uncontrolled Keywords

click chemistry; copper catalyzed alkyne-azide cycloaddition; drug delivery; lipid bodies; mitochondria; Organic chemistry;

Subjects: 1800 Chemical engineering > 1800 Chemical engineering
5400 Biochemistry > 5400 Biochemistry
Department: Institut de génie biomédical
Funders: CRSNG / NSERC, Canadian Institutes of Health Research (CIHR), Center for Self-Assembled Chemical Structure
PolyPublie URL: https://publications.polymtl.ca/3440/
Journal Title: Molecules (Basel, Switzerland) (vol. 18, no. 8)
Publisher: MDPI
DOI: 10.3390/molecules18089531
Official URL: https://doi.org/10.3390/molecules18089531
Date Deposited: 14 Dec 2018 16:48
Last Modified: 10 Nov 2022 03:51
Cite in APA 7: Avti, P. K., Maysinger, D., & Kakkar, A. (2013). Alkyne-Azide “click” chemistry in designing nanocarriers for applications in biology. Molecules (Basel, Switzerland), 18(8), 9531-9549. https://doi.org/10.3390/molecules18089531

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