Pramod K. Avti, Dusica Maysinger et Ashok Kakkar
Article de revue (2013)
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Abstract
The alkyne-azide cycloaddition, popularly known as the "click" reaction, has been extensively exploited in molecule/macromolecule build-up, and has offered tremendous potential in the design of nanomaterials for applications in a diverse range of disciplines, including biology. Some advantageous characteristics of this coupling include high efficiency, and adaptability to the environment in which the desired covalent linking of the alkyne and azide terminated moieties needs to be carried out. The efficient delivery of active pharmaceutical agents to specific organelles, employing nanocarriers developed through the use of "click" chemistry, constitutes a continuing topical area of research. In this review, we highlight important contributions click chemistry has made in the design of macromolecule-based nanomaterials for therapeutic intervention in mitochondria and lipid droplets.
Mots clés
click chemistry; copper catalyzed alkyne-azide cycloaddition; drug delivery; lipid bodies; mitochondria; Organic chemistry;
Sujet(s): |
1800 Génie chimique > 1800 Génie chimique 5400 Biochimie > 5400 Biochimie |
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Département: | Institut de génie biomédical |
Organismes subventionnaires: | CRSNG / NSERC, Canadian Institutes of Health Research (CIHR), Center for Self-Assembled Chemical Structure |
URL de PolyPublie: | https://publications.polymtl.ca/3440/ |
Titre de la revue: | Molecules (Basel, Switzerland) (vol. 18, no 8) |
Maison d'édition: | MDPI |
DOI: | 10.3390/molecules18089531 |
URL officielle: | https://doi.org/10.3390/molecules18089531 |
Date du dépôt: | 14 déc. 2018 16:48 |
Dernière modification: | 05 avr. 2024 19:35 |
Citer en APA 7: | Avti, P. K., Maysinger, D., & Kakkar, A. (2013). Alkyne-Azide “click” chemistry in designing nanocarriers for applications in biology. Molecules (Basel, Switzerland), 18(8), 9531-9549. https://doi.org/10.3390/molecules18089531 |
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