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Alkyne-Azide “click” chemistry in designing nanocarriers for applications in biology

Pramod K. Avti, Dusica Maysinger and Ashok Kakkar

Article (2013)

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Cite this document: Avti, P. K., Maysinger, D. & Kakkar, A. (2013). Alkyne-Azide “click” chemistry in designing nanocarriers for applications in biology. Molecules (Basel, Switzerland), 18(8), p. 9531-9549. doi:10.3390/molecules18089531
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Abstract

The alkyne-azide cycloaddition, popularly known as the "click" reaction, has been extensively exploited in molecule/macromolecule build-up, and has offered tremendous potential in the design of nanomaterials for applications in a diverse range of disciplines, including biology. Some advantageous characteristics of this coupling include high efficiency, and adaptability to the environment in which the desired covalent linking of the alkyne and azide terminated moieties needs to be carried out. The efficient delivery of active pharmaceutical agents to specific organelles, employing nanocarriers developed through the use of "click" chemistry, constitutes a continuing topical area of research. In this review, we highlight important contributions click chemistry has made in the design of macromolecule-based nanomaterials for therapeutic intervention in mitochondria and lipid droplets.

Uncontrolled Keywords

click chemistry; copper catalyzed alkyne-azide cycloaddition; drug delivery; lipid bodies; mitochondria; Organic chemistry;

Open Access document in PolyPublie
Subjects: 1800 Génie chimique > 1800 Génie chimique
5400 Biochimie > 5400 Biochimie
Department: Institut de génie biomédical
Research Center: Non applicable
Funders: CRSNG / NSERC, Canadian Institutes of Health Research (CIHR), Center for Self-Assembled Chemical Structure
Date Deposited: 14 Dec 2018 16:48
Last Modified: 15 Dec 2018 01:20
PolyPublie URL: https://publications.polymtl.ca/3440/
Document issued by the official publisher
Journal Title: Molecules (Basel, Switzerland) (vol. 18, no. 8)
Publisher: MDPI
Official URL: https://doi.org/10.3390/molecules18089531

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