Pradeep Kumar Thalla, Angel Contreras-García, Hicham Fadlallah, Jérémie Barrette, Gregory De Crescenzo
, Yahye Merhi and Sophie Lerouge
Article (2013)
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Open Access to the full text of this document Published Version Terms of Use: Creative Commons Attribution Download (1MB) |
Abstract
Polyethylene glycol (PEG) grafting has a great potential to create nonfouling and nonthrombogenic surfaces, but present techniques lack versatility and stability. The present work aimed to develop a versatile PEG grafting method applicable to most biomaterial surfaces, by taking advantage of novel primary amine-rich plasma-polymerized coatings. Star-shaped PEG covalent binding was studied using static contact angle, X-ray photoelectron spectroscopy (XPS), and quartz crystal microbalance with dissipation monitoring (QCM-D). Fluorescence and QCM-D both confirmed strong reduction of protein adsorption when compared to plasma-polymerized coatings and pristine poly(ethyleneterephthalate) (PET). Moreover, almost no platelet adhesion was observed after 15 min perfusion in whole blood. Altogether, our results suggest that primary amine-rich plasma-polymerized coatings offer a promising stable and versatile method for PEG grafting in order to create nonfouling and nonthrombogenic surfaces and micropatterns.
Uncontrolled Keywords
- Adsorption
- Biocompatible Materials
- Blood Platelets
- Cardiovascular Diseases
- Equipment Design
- Humans
- Microscopy, Electron, Scanning
- Microscopy, Fluorescence
- Platelet Adhesiveness
- Polyethylene Glycols
- Polyethylene Terephthalates
- Polymers
- Proteins
- Spectrometry, Fluorescence
- Spectrophotometry
- Surface Properties
- Water
- Biocompatible Materials
- Polyethylene Terephthalates
- Polymers
- Proteins
- Water
- Polyethylene Glycols
| Subjects: |
1800 Chemical engineering > 1800 Chemical engineering 2000 Materials science and technology > 2006 Biomaterials 9000 Health sciences > 9000 Health sciences |
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| Department: | Department of Chemical Engineering |
| Funders: | CRSNG / NSERC, Canadian Institutes of Health Research (CIHR) |
| PolyPublie URL: | https://publications.polymtl.ca/3423/ |
| Journal Title: | BioMed Research International (vol. 2013) |
| Publisher: | Hindawi |
| DOI: | 10.1155/2013/962376 |
| Official URL: | https://doi.org/10.1155/2013/962376 |
| Date Deposited: | 05 Dec 2018 16:08 |
| Last Modified: | 10 Apr 2025 06:32 |
| Cite in APA 7: | Thalla, P. K., Contreras-García, A., Fadlallah, H., Barrette, J., De Crescenzo, G., Merhi, Y., & Lerouge, S. (2013). A Versatile Star PEG Grafting Method for the Generation of Nonfouling and Nonthrombogenic Surfaces. BioMed Research International, 2013, 1-12. https://doi.org/10.1155/2013/962376 |
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