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A Versatile Star PEG Grafting Method for the Generation of Nonfouling and Nonthrombogenic Surfaces

Pradeep Kumar Thalla, Angel Contreras-García, Hicham Fadlallah, Jérémie Barrette, Gregory De Crescenzo, Yahye Merhi, Sophie Lerouge

Article (2013)

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Polyethylene glycol (PEG) grafting has a great potential to create nonfouling and nonthrombogenic surfaces, but present techniques lack versatility and stability. The present work aimed to develop a versatile PEG grafting method applicable to most biomaterial surfaces, by taking advantage of novel primary amine-rich plasma-polymerized coatings. Star-shaped PEG covalent binding was studied using static contact angle, X-ray photoelectron spectroscopy (XPS), and quartz crystal microbalance with dissipation monitoring (QCM-D). Fluorescence and QCM-D both confirmed strong reduction of protein adsorption when compared to plasma-polymerized coatings and pristine poly(ethyleneterephthalate) (PET). Moreover, almost no platelet adhesion was observed after 15 min perfusion in whole blood. Altogether, our results suggest that primary amine-rich plasma-polymerized coatings offer a promising stable and versatile method for PEG grafting in order to create nonfouling and nonthrombogenic surfaces and micropatterns.

Uncontrolled Keywords

Adsorption; Biocompatible Materials; Blood Platelets; Cardiovascular Diseases; Equipment Design; Humans; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Platelet Adhesiveness; Polyethylene Glycols; Polyethylene Terephthalates; Polymers; Proteins; Spectrometry, Fluorescence; Spectrophotometry; Surface Properties; Water; Biocompatible Materials; Polyethylene Terephthalates; Polymers; Proteins; Water; Polyethylene Glycols

Subjects: 1800 Chemical engineering > 1800 Chemical engineering
2000 Materials science and technology > 2006 Biomaterials
9000 Health sciences > 9000 Health sciences
Department: Department of Chemical Engineering
Funders: CRSNG / NSERC, Canadian Institutes of Health Research (CIHR)
PolyPublie URL: https://publications.polymtl.ca/3423/
Journal Title: BioMed Research International (vol. 2013)
Publisher: Hindawi
DOI: 10.1155/2013/962376
Official URL: https://doi.org/10.1155/2013/962376
Date Deposited: 05 Dec 2018 16:08
Last Modified: 11 Nov 2022 13:28
Cite in APA 7: Thalla, P. K., Contreras-García, A., Fadlallah, H., Barrette, J., De Crescenzo, G., Merhi, Y., & Lerouge, S. (2013). A Versatile Star PEG Grafting Method for the Generation of Nonfouling and Nonthrombogenic Surfaces. BioMed Research International, 2013. https://doi.org/10.1155/2013/962376


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