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Time-dependent integrity during storage of natural surface water samples for the trace analysis of pharmaceutical products, feminizing hormones and pesticides

Khadija Aboulfadl, Cyril De Potter, Michèle Prévost and Sébastien Sauvé

Article (2010)

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Monitoring and analysis of trace contaminants such as pharmaceuticals and pesticides require the preservation of the samples before they can be quantified using the appropriate analytical methods. Our objective is to determine the sample shelf life to insure proper quantification of ultratrace contaminants. To this end, we tested the stability of a variety of pharmaceutical products including caffeine, natural steroids, and selected pesticides under refrigerated storage conditions. The analysis was performed using multi-residue methods using an on-line solid-phase extraction combined with liquid chromatography tandem mass spectrometry (SPE-LC-MS/MS) in the selected reaction monitoring mode. After 21 days of storage, no significant difference in the recoveries was observed compared to day 0 for pharmaceutical products, while for pesticides, significant losses occurred for DIA and simazine after 10 days (14% and 17% reduction respectively) and a statistically significant decrease in the recovery was noted for cyanazine (78% disappearance). However, the estrogen and progestogen steroids were unstable during storage. The disappearance rates obtained after 21 days of storage vary from 63 to 72% for the feminizing hormones. Overall, pharmaceuticals and pesticides seem to be stable for refrigerated storage for up to about 10 days (except cyanazine) and steroidal hormones can be quite sensitive to degradation and should not be stored for more than a few days.

Uncontrolled Keywords

Chemistry/Food Science; general

Subjects: 1000 Civil engineering > 1000 Civil engineering
1000 Civil engineering > 1007 Water resources and supply
3500 Analytical chemistry > 3500 Analytical chemistry
Department: Department of Civil, Geological and Mining Engineering
Research Center: CIEP - Industrial Chair on Drinking Water
Funders: CRSNG/NSERC, Chaire industrielle CRSNG en eau potable (CICEP)
PolyPublie URL: https://publications.polymtl.ca/3397/
Journal Title: Chemistry Central Journal (vol. 4, no. 1)
Publisher: BioMed Central
DOI: 10.1186/1752-153x-4-10
Official URL: https://doi.org/10.1186/1752-153x-4-10
Date Deposited: 10 Jan 2019 12:49
Last Modified: 01 Nov 2023 13:16
Cite in APA 7: Aboulfadl, K., De Potter, C., Prévost, M., & Sauvé, S. (2010). Time-dependent integrity during storage of natural surface water samples for the trace analysis of pharmaceutical products, feminizing hormones and pesticides. Chemistry Central Journal, 4(1). https://doi.org/10.1186/1752-153x-4-10


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