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Effect of pathology type and severity on the distribution of MRI signal intensities within the degenerated nucleus pulposus: application to idiopathic scoliosis and spondylolisthesis

Delphine Périé-Curnier and Daniel Curnier

Article (2010)

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Cite this document: Périé-Curnier, D. & Curnier, D. (2010). Effect of pathology type and severity on the distribution of MRI signal intensities within the degenerated nucleus pulposus: application to idiopathic scoliosis and spondylolisthesis. BMC Musculoskeletal Disorders, 11. doi:10.1186/1471-2474-11-189
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Abstract

Background: Disc degeneration is characterized by a loss of cellularity, degradation of the extracellular matrix, and, as a result, morphological changes and biomechanical alterations. We hypothesized that the distribution of the MR signal intensity within the nucleus zone of the intervertebral disc was modified according to the pathology and the severity of the pathology. The objective of this study was to propose new parameters characterizing the distribution of the signal intensity within the nucleus zone of lumbar intervertebral discs, and to quantify these changes in patients suffering from spondylolisthesis or idiopathic scoliosis.Methods: A retrospective study had been performed on T2-weighted MR images of twenty nine patients suffering from spondylolisthesis and/or scoliosis. The high intensity zone of the nucleus pulposus was semi-automatically detected. The distance "DX" between the center weighted by the signal intensity and the geometrical center was quantified. The sum of the signal intensity on the axis perpendicular to the longitudinal axis of the disc was plotted for each position of the longitudinal axis allowing defining the maximum sum "SM" and its position "PSM".Results: "SM" was clearly higher and "PSM" was more shifted for scoliosis than for spondylolisthesis. A two-way analysis of variance showed that the differences observed on "DX" were not attributed to the pathology nor its severity, the differences observed on "SM" were attributed to the pathology but not to its severity, and the differences observed on "PSM" were attributed to both the pathology and its severity.Conclusions: The technique proposed in this study showed significant differences in the distribution of the MR signal intensity within the nucleus zone of intervertebral discs due to the pathology and its severity. The dependence of the "PSM" parameter to the severity of the pathology suggests this parameter as a predictive factor of the pathology progression. This new technique should be useful for the early diagnosis of intervertebral disc pathologies as it highlights abnormal patterns in the MRI signal for low severity of the pathology.

Uncontrolled Keywords

Adolescent; Child; Child, Preschool; Female; Humans; Intervertebral Disc; Intervertebral Disc Degeneration; Magnetic Resonance Imaging; Male; Retrospective Studies; Scoliosis; Severity of Illness Index; Spondylolisthesis

Open Access document in PolyPublie
Subjects: 2100 Génie mécanique > 2100 Génie mécanique
9000 Sciences médicales > 9000 Sciences médicales
Department: Département de génie mécanique
Research Center: Non applicable
Date Deposited: 13 Dec 2018 14:55
Last Modified: 14 Dec 2018 01:20
PolyPublie URL: https://publications.polymtl.ca/3396/
Document issued by the official publisher
Journal Title: BMC Musculoskeletal Disorders (vol. 11)
Publisher: BioMed Central
Official URL: https://doi.org/10.1186/1471-2474-11-189

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