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Investigating the human spinal sensorimotor pathways through functional magnetic resonance imaging

Caroline Landelle, Ovidiu Lungu, Shahabeddin Vahdat, Anne Kavounoudias, Veronique Marchand-Pauvert, Benjamin De Leener et Julien Doyon

Article de revue (2021)

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Abstract

Most of our knowledge about the human spinal ascending (sensory) and descending (motor) pathways comes from non-invasive electrophysiological investigations. However, recent methodological advances in acquisition and analyses of functional magnetic resonance imaging (fMRI) data from the spinal cord, either alone or in combination with the brain, have allowed us to gain further insights into the organization of this structure. In the current review, we conducted a systematic search to produced somatotopic maps of the spinal fMRI activity observed through different somatosensory, motor and resting-state paradigms. By cross-referencing these human neuroimaging findings with knowledge acquired through neurophysiological recordings, our review demonstrates that spinal fMRI is a powerful tool for exploring, in vivo, the human spinal cord pathways. We report strong cross-validation between task-related and resting-state fMRI in accordance with well-known hemicord, postero-anterior and rostro-caudal organization of these pathways. We also highlight the specific advantages of using spinal fMRI in clinical settings to characterize better spinal-related impairments, predict disease progression, and guide the implementation of therapeutic interventions.

Mots clés

Humans; Magnetic Resonance Imaging/*methods; Spinal Cord/anatomy & histology/*diagnostic imaging/*physiology; *Motor; *Proprioception; *Sensorimotor pathways; *Spinal-cord FMRI; *Touch; *resting-state; competing financial interests or personal relationships that could have appeared; to influence the work reported in this paper.;

Sujet(s): 1900 Génie biomédical > 1900 Génie biomédical
2500 Génie électrique et électronique > 2500 Génie électrique et électronique
Département: Département de génie informatique et génie logiciel
Organismes subventionnaires: Fondation Courtois, Natural Sciences and Engineering Research Council of Canada (NSERC), Fonds de Recherche du Québec –Santé (FRQ-S)
Numéro de subvention: RGPIN- 2020–05242
URL de PolyPublie: https://publications.polymtl.ca/10646/
Titre de la revue: NeuroImage (vol. 245)
Maison d'édition: Elsevier
DOI: 10.1016/j.neuroimage.2021.118684
URL officielle: https://doi.org/10.1016/j.neuroimage.2021.118684
Date du dépôt: 18 juil. 2023 12:10
Dernière modification: 25 oct. 2024 14:22
Citer en APA 7: Landelle, C., Lungu, O., Vahdat, S., Kavounoudias, A., Marchand-Pauvert, V., De Leener, B., & Doyon, J. (2021). Investigating the human spinal sensorimotor pathways through functional magnetic resonance imaging. NeuroImage, 245, 118684. https://doi.org/10.1016/j.neuroimage.2021.118684

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