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Intellectual impairment in school-age children exposed to manganese from drinking water

Maryse F. Bouchard, Sébastien Sauve, Benoit Barbeau, Mélissa Legrand, Marie-Eve Brodeur, Thérèse Bouffard, Elyse Limoges, David C. Bellinger and Donna Mergler

Article (2011)

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Abstract

BACKGROUND: Manganese is an essential nutrient, but in excess it can be a potent neurotoxicant. Despite the common occurrence of manganese in groundwater, the risks associated with this source of exposure are largely unknown.

OBJECTIVES: Our first aim was to assess the relations between exposure to manganese from drinking water and children's intelligence quotient (IQ). Second, we examined the relations between manganese exposures from water consumption and from the diet with children's hair manganese concentration.

METHODS: This cross-sectional study included 362 children 6-13 years of age living in communities supplied by groundwater. Manganese concentration was measured in home tap water (MnW) and children's hair (MnH). We estimated manganese intake from water ingestion and the diet using a food frequency questionnaire and assessed IQ with the Wechsler Abbreviated Scale of Intelligence.

RESULTS: The median MnW in children's home tap water was 34 microg/L (range, 1-2,700 microg/L). MnH increased with manganese intake from water consumption, but not with dietary manganese intake. Higher MnW and MnH were significantly associated with lower IQ scores. A 10-fold increase in MnW was associated with a decrease of 2.4 IQ points (95% confidence interval: -3.9 to -0.9; p < 0.01), adjusting for maternal intelligence, family income, and other potential confounders. There was a 6.2-point difference in IQ between children in the lowest and highest MnW quintiles. MnW was more strongly associated with Performance IQ than Verbal IQ. CONCLUSIONS: The findings of this cross-sectional study suggest that exposure to manganese at levels common in groundwater is associated with intellectual impairment in children.

Uncontrolled Keywords

Adolescent; Child; Cross-Sectional Studies; Diet/statistics & numerical data; Environmental Exposure/analysis/*statistics & numerical data; Female; Hair/metabolism; Humans; Intelligence/*drug effects; Male; Manganese/analysis/metabolism/*toxicity; Students/*statistics & numerical data; Surveys and Questionnaires; Water Pollutants, Chemical/analysis/metabolism/*toxicity; Water Supply/analysis;

Additional Information: Articles dans le domaine public
Subjects: 1500 Environmental engineering > 1500 Environmental engineering
1500 Environmental engineering > 1501 Water quality, pollution
6300 Psychology > 6311 Motor systems and performance
Department: Department of Civil, Geological and Mining Engineering
Research Center: CIEP - Industrial Chair on Drinking Water
Funders: Canadian Institutes for Health Research
Grant number: NRF-82899
PolyPublie URL: https://publications.polymtl.ca/10607/
Edition: 2010/09/22th ed.
Journal Title: Environmental Health Perspectives (vol. 119, no. 1)
Publisher: Environmental Health Perspectives
DOI: 10.1289/ehp.1002321
Official URL: https://doi.org/10.1289/ehp.1002321
Date Deposited: 18 Jul 2023 15:42
Last Modified: 06 Apr 2024 07:31
Cite in APA 7: Bouchard, M. F., Sauve, S., Barbeau, B., Legrand, M., Brodeur, M.-E., Bouffard, T., Limoges, E., Bellinger, D. C., & Mergler, D. (2011). Intellectual impairment in school-age children exposed to manganese from drinking water. Environmental Health Perspectives, 119(1), 138-143. https://doi.org/10.1289/ehp.1002321

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