Alberto Lazari, Mohamed Tachrount, Juan Miguel Valverde, Daniel S. Papp, Antoine Beauchamp, Paul McCarthy, Jacob Ellegood, Joanes Grandjean, Heidi Johansen‐Berg, Valerio Zerbi, Jason P. Lerch et Rogier B. Mars
Article de revue (2024)
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Abstract
While humans are known to have several premotor cortical areas, secondary motor cortex (M2) is often considered to be the only higher-order motor area of the mouse brain and is thought to combine properties of various human premotor cortices. Here, we show that axonal tracer, functional connectivity, myelin mapping, gene expression, and optogenetics data contradict this notion. Our analyses reveal three premotor areas in the mouse, anterior-lateral motor cortex (ALM), anterior-lateral M2 (aM2), and posterior-medial M2 (pM2), with distinct structural, functional, and behavioral properties. By using the same techniques across mice and humans, we show that ALM has strikingly similar functional and microstructural properties to human anterior ventral premotor areas and that aM2 and pM2 amalgamate properties of human pre-SMA and cingulate cortex. These results provide evidence for the existence of multiple premotor areas in the mouse and chart a comparative map between the motor systems of humans and mice.
Mots clés
comparative neuroanatomy; translational neuroscience; cross-species neuroimaging; myelin; connectivity; premotormotor
Renseignements supplémentaires: |
Supplemental information : ; Document S1. Figures S1–S7 and Tables S1 and S2 : https://ars.els-cdn.com/content/image/1-s2.0-S2211124724005199-mmc1.pdf ; Document S2. Article plus supplemental information : https://ars.els-cdn.com/content/image/1-s2.0-S2211124724005199-mmc3.pdf |
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Sujet(s): |
1900 Génie biomédical > 1900 Génie biomédical 1900 Génie biomédical > 1903 Biomécanique |
Département: | Institut de génie biomédical |
Centre de recherche: | NeuroPoly - Laboratoire de Recherche en Neuroimagerie |
Organismes subventionnaires: | Wellcome Centre for Integrative Neuroimaging, EPA Cephalosporin Fund, Biotechnology and Biological Sciences Research Council, European Union's Horizon 2020 Framework Program, Otto A. Malm Foundation, Swiss National Science Foundation (SNSF) Ambizione, ECCELLENZA |
Numéro de subvention: | BB/N019814/1, BB/X013227/1, 740264 [GENOMMED], PZ00P3_173984/1, PCEFP3_203005, 203139/Z/16/Z, 110027/ Z/15/Z, 203139/Z/16/Z |
URL de PolyPublie: | https://publications.polymtl.ca/58554/ |
Titre de la revue: | Cell Report (vol. 43, no 5) |
Maison d'édition: | Elsevier |
DOI: | 10.1016/j.celrep.2024.114191 |
URL officielle: | https://doi.org/10.1016/j.celrep.2024.114191 |
Date du dépôt: | 11 juin 2024 09:50 |
Dernière modification: | 12 juin 2024 04:30 |
Citer en APA 7: | Lazari, A., Tachrount, M., Valverde, J. M., Papp, D. S., Beauchamp, A., McCarthy, P., Ellegood, J., Grandjean, J., Johansen‐Berg, H., Zerbi, V., Lerch, J. P., & Mars, R. B. (2024). The mouse motor system contains multiple premotor areas and partially follows human organizational principles. Cell Report, 43(5), 11491 (19 pages). https://doi.org/10.1016/j.celrep.2024.114191 |
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