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Interstitial imaging with multiple diffusive reflectance spectroscopy projections for in vivo blood vessels detection during brain needle biopsy procedures

Fabien Picot, Andréanne Goyette, Sami Obaid, Joannie Desroches, Simon Lessard, Marie-Andrée Tremblay, Mathias Strupler, Brian Wilson, Kevin Petrecca, Gilles Soulez et Frédéric Leblond

Article de revue (2019)

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Abstract

Blood vessel injury during image-guided brain biopsy poses a risk of hemorrhage. Approaches that reduce this risk may minimize related patient morbidity. We present here an intraoperative imaging device that has the potential to detect the brain vasculature in situ. The device uses multiple diffuse reflectance spectra acquired in an outward-viewing geometry to detect intravascular hemoglobin, enabling the construction of an optical image in the vicinity of the biopsy needle revealing the proximity to blood vessels. This optical detection system seamlessly integrates into a commercial biopsy system without disrupting the neurosurgical clinical workflow. Using diffusive brain tissue phantoms, we show that this device can detect 0.5-mm diameter absorptive carbon rods up to approximately 2 mm from the biopsy window. We also demonstrate feasibility and practicality of the technique in a clinical environment to detect brain vasculature in an in vivo model system. In situ brain vascular detection may add a layer of safety to image-guided biopsies and minimize patient morbidity.

Mots clés

biopsy; diffuse reflectance; light transport; optics; spectroscopy; surgery; tissue optics; tomography

Sujet(s): 2500 Génie électrique et électronique > 2505 Dispositifs et réseaux photoniques
3100 Physique > 3100 Physique
Département: Département de génie physique
Organismes subventionnaires: CRSNG/NSERC, Collaborative Health Research Program (CIHR and NSERC), Medtronic
URL de PolyPublie: https://publications.polymtl.ca/5086/
Titre de la revue: Neurophotonics (vol. 6, no 2)
Maison d'édition: SPIE
DOI: 10.1117/1.nph.6.2.025003
URL officielle: https://doi.org/10.1117/1.nph.6.2.025003
Date du dépôt: 04 août 2022 14:48
Dernière modification: 25 mai 2023 09:25
Citer en APA 7: Picot, F., Goyette, A., Obaid, S., Desroches, J., Lessard, S., Tremblay, M.-A., Strupler, M., Wilson, B., Petrecca, K., Soulez, G., & Leblond, F. (2019). Interstitial imaging with multiple diffusive reflectance spectroscopy projections for in vivo blood vessels detection during brain needle biopsy procedures. Neurophotonics, 6(2), 025003 (8 pages). https://doi.org/10.1117/1.nph.6.2.025003

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