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Interstitial imaging with multiple diffusive reflectance spectroscopy projections for in vivo blood vessels detection during brain needle biopsy procedures

Fabien Picot, Andréanne Goyette, Sami Obaid, Joannie Desroches, Simon Lessard, Marie-Andrée Tremblay, Mathias Strupler, Brian Wilson, Kevin Petrecca, Gilles Soulez and Frédéric Leblond

Article (2019)

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Abstract

Blood vessel injury during image-guided brain biopsy poses a risk of hemorrhage. Approaches that reduce this risk may minimize related patient morbidity. We present here an intraoperative imaging device that has the potential to detect the brain vasculature in situ. The device uses multiple diffuse reflectance spectra acquired in an outward-viewing geometry to detect intravascular hemoglobin, enabling the construction of an optical image in the vicinity of the biopsy needle revealing the proximity to blood vessels. This optical detection system seamlessly integrates into a commercial biopsy system without disrupting the neurosurgical clinical workflow. Using diffusive brain tissue phantoms, we show that this device can detect 0.5-mm diameter absorptive carbon rods up to approximately 2 mm from the biopsy window. We also demonstrate feasibility and practicality of the technique in a clinical environment to detect brain vasculature in an in vivo model system. In situ brain vascular detection may add a layer of safety to image-guided biopsies and minimize patient morbidity.

Uncontrolled Keywords

biopsy; diffuse reflectance; light transport; optics; spectroscopy; surgery; tissue optics; tomography

Subjects: 2500 Electrical and electronic engineering > 2505 Photonic devices and networks
3100 Physics > 3100 Physics
Department: Department of Engineering Physics
Funders: CRSNG/NSERC, Collaborative Health Research Program (CIHR and NSERC), Medtronic
PolyPublie URL: https://publications.polymtl.ca/5086/
Journal Title: Neurophotonics (vol. 6, no. 2)
Publisher: SPIE
DOI: 10.1117/1.nph.6.2.025003
Official URL: https://doi.org/10.1117/1.nph.6.2.025003
Date Deposited: 04 Aug 2022 14:48
Last Modified: 25 May 2023 09:25
Cite in APA 7: Picot, F., Goyette, A., Obaid, S., Desroches, J., Lessard, S., Tremblay, M.-A., Strupler, M., Wilson, B., Petrecca, K., Soulez, G., & Leblond, F. (2019). Interstitial imaging with multiple diffusive reflectance spectroscopy projections for in vivo blood vessels detection during brain needle biopsy procedures. Neurophotonics, 6(2), 025003 (8 pages). https://doi.org/10.1117/1.nph.6.2.025003

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