Fabien Picot, Andréanne Goyette, Sami Obaid, Joannie Desroches, Simon Lessard, Marie-Andrée Tremblay, Mathias Strupler, Brian Wilson, Kevin Petrecca, Gilles Soulez and Frédéric Leblond
Article (2019)
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Open Access to the full text of this document Published Version Terms of Use: Creative Commons Attribution Download (736kB) |
Abstract
Blood vessel injury during image-guided brain biopsy poses a risk of hemorrhage. Approaches that reduce this risk may minimize related patient morbidity. We present here an intraoperative imaging device that has the potential to detect the brain vasculature in situ. The device uses multiple diffuse reflectance spectra acquired in an outward-viewing geometry to detect intravascular hemoglobin, enabling the construction of an optical image in the vicinity of the biopsy needle revealing the proximity to blood vessels. This optical detection system seamlessly integrates into a commercial biopsy system without disrupting the neurosurgical clinical workflow. Using diffusive brain tissue phantoms, we show that this device can detect 0.5-mm diameter absorptive carbon rods up to approximately 2 mm from the biopsy window. We also demonstrate feasibility and practicality of the technique in a clinical environment to detect brain vasculature in an in vivo model system. In situ brain vascular detection may add a layer of safety to image-guided biopsies and minimize patient morbidity.
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Subjects: |
2500 Electrical and electronic engineering > 2505 Photonic devices and networks 3100 Physics > 3100 Physics |
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Department: | Department of Engineering Physics |
Funders: | CRSNG/NSERC, Collaborative Health Research Program (CIHR and NSERC), Medtronic |
PolyPublie URL: | https://publications.polymtl.ca/5086/ |
Journal Title: | Neurophotonics (vol. 6, no. 2) |
Publisher: | SPIE |
DOI: | 10.1117/1.nph.6.2.025003 |
Official URL: | https://doi.org/10.1117/1.nph.6.2.025003 |
Date Deposited: | 04 Aug 2022 14:48 |
Last Modified: | 07 Apr 2025 21:25 |
Cite in APA 7: | Picot, F., Goyette, A., Obaid, S., Desroches, J., Lessard, S., Tremblay, M.-A., Strupler, M., Wilson, B., Petrecca, K., Soulez, G., & Leblond, F. (2019). Interstitial imaging with multiple diffusive reflectance spectroscopy projections for in vivo blood vessels detection during brain needle biopsy procedures. Neurophotonics, 6(2), 025003 (8 pages). https://doi.org/10.1117/1.nph.6.2.025003 |
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