<  Back to the Polytechnique Montréal portal

High impact exercise improves bone microstructure and strength in growing rats

Tanvir Mustafy, Irène Londono, Florina Moldovan and Isabelle Villemure

Article (2019)

Open Acess document in PolyPublie and at official publisher
[img]
Preview
Open Access to the full text of this document
Published Version
Terms of Use: Creative Commons Attribution
Download (870kB)
Show abstract
Hide abstract

Abstract

Physical activity is beneficial for skeletal development. However, impact sports during adolescence, leading to bone growth retardation and/or bone quality improvement, remains unexplained. This study investigated the effects of in vivo low (LI), medium (MI), and high (HI) impact loadings applied during puberty on bone growth, morphometry and biomechanics using a rat model. 4-week old rats (n = 30) were divided into control, sham, LI, MI, and HI groups. The impact was applied on the right tibiae, 5 days/week for 8 weeks mimicking walking (450 microepsilon), uphill running (850 microepsilon) and jumping (1250 microepsilon) conditions. Trabecular and cortical parameters were determined by micro-CT, bone growth rate by calcein labeling and toluidine blue staining followed by histomorphometry. Bio-mechanical properties were evaluated from bending tests. HI group reduced rat body weight and food consumption compared to shams. Bone growth rate also decreased in MI and HI groups despite developing thicker hypertrophic and proliferative zone heights. HI group showed significant increment in bone mineral density, trabecular thickness, cortical and total surface area. Ultimate load and stiffness were also increased in MI and HI groups. We conclude that impact loading during adolescence reduces bone growth moderately but improves bone quality and biomechanics at the end of the growing period.

Subjects: 2100 Mechanical engineering > 2100 Mechanical engineering
6400 Life sciences research related to human health and disease > 6400 Life sciences research related to human health and disease
Department: Department of Mechanical Engineering
Funders: CRSNG/NSERC, CRC Program (IV), NSERC/CREATE program (TM)
PolyPublie URL: https://publications.polymtl.ca/5043/
Journal Title: Scientific Reports (vol. 9, no. 1)
Publisher: Nature
DOI: 10.1038/s41598-019-49432-2
Official URL: https://doi.org/10.1038/s41598-019-49432-2
Date Deposited: 04 Aug 2022 14:30
Last Modified: 14 May 2023 21:31
Cite in APA 7: Mustafy, T., Londono, I., Moldovan, F., & Villemure, I. (2019). High impact exercise improves bone microstructure and strength in growing rats. Scientific Reports, 9(1), 13128. https://doi.org/10.1038/s41598-019-49432-2

Statistics

Total downloads

Downloads per month in the last year

Origin of downloads

Dimensions

Repository Staff Only

View Item View Item