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High impact exercise improves bone microstructure and strength in growing rats

Tanvir Mustafy, Irène Londono, Florina Moldovan et Isabelle Villemure

Article de revue (2019)

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Abstract

Physical activity is beneficial for skeletal development. However, impact sports during adolescence, leading to bone growth retardation and/or bone quality improvement, remains unexplained. This study investigated the effects of in vivo low (LI), medium (MI), and high (HI) impact loadings applied during puberty on bone growth, morphometry and biomechanics using a rat model. 4-week old rats (n = 30) were divided into control, sham, LI, MI, and HI groups. The impact was applied on the right tibiae, 5 days/week for 8 weeks mimicking walking (450 microepsilon), uphill running (850 microepsilon) and jumping (1250 microepsilon) conditions. Trabecular and cortical parameters were determined by micro-CT, bone growth rate by calcein labeling and toluidine blue staining followed by histomorphometry. Bio-mechanical properties were evaluated from bending tests. HI group reduced rat body weight and food consumption compared to shams. Bone growth rate also decreased in MI and HI groups despite developing thicker hypertrophic and proliferative zone heights. HI group showed significant increment in bone mineral density, trabecular thickness, cortical and total surface area. Ultimate load and stiffness were also increased in MI and HI groups. We conclude that impact loading during adolescence reduces bone growth moderately but improves bone quality and biomechanics at the end of the growing period.

Sujet(s): 2100 Génie mécanique > 2100 Génie mécanique
6400 Recherche en sciences de la vie liées à la santé publique et aux maladies humaines > 6400 Recherche en sciences de la vie liées à la santé publique et aux maladies humaines
Département: Département de génie mécanique
Organismes subventionnaires: CRSNG/NSERC, CRC Program (IV), NSERC/CREATE program (TM)
URL de PolyPublie: https://publications.polymtl.ca/5043/
Titre de la revue: Scientific Reports (vol. 9, no 1)
Maison d'édition: Nature
DOI: 10.1038/s41598-019-49432-2
URL officielle: https://doi.org/10.1038/s41598-019-49432-2
Date du dépôt: 04 août 2022 14:30
Dernière modification: 14 mai 2023 21:31
Citer en APA 7: Mustafy, T., Londono, I., Moldovan, F., & Villemure, I. (2019). High impact exercise improves bone microstructure and strength in growing rats. Scientific Reports, 9(1), 13128. https://doi.org/10.1038/s41598-019-49432-2

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