Rachel R. P. Machado, Elton Soares de Lima Filho, Rafael C. Dutra, Nádia R. Barbosa Raposo, Rafael S. Duarte, Geraldo Luiz G. Soares, Bernhard Lesche and Maria Auxiliadora C. Kaplan
Article (2012)
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Published Version Terms of Use: Creative Commons Attribution . Download (3MB) |
Cite this document: | Machado, R. R. P., Soares de Lima Filho, E., Dutra, R. C., Barbosa Raposo, N. R., Duarte, R. S., Soares, G. L. G., ... Kaplan, M. A. C. (2012). Metabolic Activity Interferometer: A Powerful Tool for Testing Antibiotics. Journal of Sensors, 2012, p. 1-7. doi:10.1155/2012/493797 |
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Abstract
It is demonstrated that the efficiency of antibiotics can be tested using an interferometric method. Two antibiotics were used as models to show that an interferometric method to monitor the metabolic activity of slowly growing bacteria can be a safer method to judge antimicrobial properties of substances than conventional methods. The susceptibility of Mycobacterium bovis to hexane extract of Pterodon emarginatus and to the well-known antibiotic rifampicin was tested with the interferometric method and with the conventional microplate method. The microplate method revealed a potential activity of hexane extract against M. bovis. However, the interferometric method showed that the action of this substance is rather limited. Also in the case of rifampicin, the interferometric method was able to detect resistant bacteria.
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Subjects: |
5200 Microbiologie > 5201 Bactériologie 9000 Sciences de la santé > 9000 Sciences de la santé |
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Department: | Département de génie physique |
Research Center: | Non applicable |
Funders: | Fundação de Amparo a Pesquisa e Extensão de Minas Gerais (FAPEMIG) |
Grant number: | APQ-00246-10 |
Date Deposited: | 03 Dec 2018 15:07 |
Last Modified: | 08 Apr 2021 10:43 |
PolyPublie URL: | https://publications.polymtl.ca/3418/ |
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Journal Title: | Journal of Sensors (vol. 2012) |
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Publisher: | Hindawi |
Official URL: | https://doi.org/10.1155/2012/493797 |
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