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Metabolic Activity Interferometer: A Powerful Tool for Testing Antibiotics

Rachel R. P. Machado, Elton Soares de Lima Filho, Rafael C. Dutra, Nádia R. Barbosa Raposo, Rafael S. Duarte, Geraldo Luiz G. Soares, Bernhard Lesche and Maria Auxiliadora C. Kaplan

Article (2012)

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Cite this document: Machado, R. R. P., Soares de Lima Filho, E., Dutra, R. C., Barbosa Raposo, N. R., Duarte, R. S., Soares, G. L. G., ... Kaplan, M. A. C. (2012). Metabolic Activity Interferometer: A Powerful Tool for Testing Antibiotics. Journal of Sensors, 2012, p. 1-7. doi:10.1155/2012/493797
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It is demonstrated that the efficiency of antibiotics can be tested using an interferometric method. Two antibiotics were used as models to show that an interferometric method to monitor the metabolic activity of slowly growing bacteria can be a safer method to judge antimicrobial properties of substances than conventional methods. The susceptibility of Mycobacterium bovis to hexane extract of Pterodon emarginatus and to the well-known antibiotic rifampicin was tested with the interferometric method and with the conventional microplate method. The microplate method revealed a potential activity of hexane extract against M. bovis. However, the interferometric method showed that the action of this substance is rather limited. Also in the case of rifampicin, the interferometric method was able to detect resistant bacteria.

Open Access document in PolyPublie
Subjects: 5200 Microbiologie > 5201 Bactériologie
9000 Sciences de la santé > 9000 Sciences de la santé
Department: Département de génie physique
Research Center: Non applicable
Funders: Fundação de Amparo a Pesquisa e Extensão de Minas Gerais (FAPEMIG)
Grant number: APQ-00246-10
Date Deposited: 03 Dec 2018 15:07
Last Modified: 08 Apr 2021 10:43
PolyPublie URL: https://publications.polymtl.ca/3418/
Document issued by the official publisher
Journal Title: Journal of Sensors (vol. 2012)
Publisher: Hindawi
Official URL: https://doi.org/10.1155/2012/493797


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